Main Cast of Grey's Anatomy Season 22 Episode 1
Season 22 episode 1 features the core ensemble led by Ellen Pompeo as Meredith Grey, Chandra Wilson as Miranda Bailey, and Justin Chambers as Alex Karev. Other returning regulars include James Pickens Jr. as Richard Webber, Kevin McKidd as Owen Hunt, and Caterina Scorsone as Amelia Shepherd.
Guest Stars and New Faces
Episode 1 introduces new surgical interns and recurring characters, with select guest actors filling key hospital roles. For a full list of guest appearances, the Grey's Anatomy official ABC page provides updated cast details.
Where to Watch and Episode Focus
Grey's Anatomy season 22 episode 1 continues the series' medical drama format, focusing on the personal and professional challenges faced by the doctors at Grey Sloan Memorial. The episode is available to stream on Hulu and ABC's official platforms.
